Macrophages as a “weapon” in anticancer cellular immunotherapy

Dmitry Aminin*, Yun-Ming Wang

*此作品的通信作者

研究成果: Review article同行評審

37 引文 斯高帕斯(Scopus)

摘要

Anticancer immunotherapy is a treatment that activates the immune system to fight the tumor. Immunotherapy has several advantages over other cancer treatments in that anticancer immunotherapy displays high specificity, low side effects, and can combine with various conventional therapies. In recent years, oncologists have shown increasing interest in using macrophages for adoptive cell therapy and predict a bright future of macrophage-directed therapy for eliminating cancer. The focus of increased research interest is the classically activated M1 macrophages exhibiting pronounced tumoricidal activity, and the alternatively activated M2 tumor-associated macrophages, which otherwise help malignant cells evading attack by the immune system. M1 macrophages may represent an effective weapon in anticancer cellular immunotherapy, and the use of autoimmune macrophages properly prepared for antitumor administration is one of the promising ways for personalized therapy of cancer patients. The present report mainly discusses some modern aspects of the problem in application of activated M1 macrophage in anticancer therapy and reviews relevant publications up to 2021.

原文English
頁(從 - 到)749-758
頁數10
期刊Kaohsiung Journal of Medical Sciences
37
發行號9
DOIs
出版狀態Published - 9月 2021

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