Long-term stability of axonal boutons in the mouse barrel cortex

Qian Qiao, Lei Ma, Wei Li, Jin Wu Tsai, Guang Yang, Wen Biao Gan*


研究成果: Article同行評審

30 引文 斯高帕斯(Scopus)


Many lines of evidence indicate that postsynaptic dendritic spines are plastic during development and largely stable in adulthood. It remains unclear to what degree presynaptic axonal terminals undergo changes in the developing and mature cortex. In this study, we examined the formation and elimination of fluorescently-labeled axonal boutons in the living mouse barrel cortex with transcranial two-photon microscopy. We found that the turnover of axonal boutons was significantly higher in 3-week-old young mice than in adult mice (older than 3 months). There was a slight but significant net loss of axonal boutons in mice from 1 to 2 months of age. In both young and adult barrel cortex, axonal boutons existed for at least 1 week were less likely to be eliminated than those recently-formed boutons. In adulthood, 80% of axonal boutons persisted over 12 months and enriched sensory experience caused a slight but not significant increase in the turnover of axonal boutons over 2-4 weeks. Thus, similar to postsynaptic dendritic spines, presynaptic axonal boutons show remarkable stability after development ends. This long-term stability of synaptic connections is likely important for reliable sensory processing in the mature somatosensory cortex.

頁(從 - 到)252-261
期刊Developmental Neurobiology
出版狀態Published - 1 3月 2016


深入研究「Long-term stability of axonal boutons in the mouse barrel cortex」主題。共同形成了獨特的指紋。