Locational effects on oral microbiota among long-term care patients

Fa Tzu Tsai*, Ding-Han Wang*, Cheng-Chieh Yang, Yu Cheng Lin, Lin Jack Huang, Wei Yu Tsai, Chang Wei Li, Wun Eng Hsu, Hsi-Feng Tu*, Ming-Lun Hsu*


研究成果: Article同行評審


Background: Dysbiosis of oral microbiota is the cause of many diseases related to oral and general health. However, few Asia-based studies have evaluated the role of oral microbiota in patients receiving long-term care. Thus, new indications are needed for early prevention and risk management based on information derived from the oral microbiota. Methods: We used next-generation sequencing (NGS) to identify the oral bacterial composition and abundance in patients receiving long-term care: 20 from the outpatient department (OPD) and 20 home-care patients. Their microbial compositions, taxonomy, and alpha/beta diversity were characterized. Results: Microbiota from the two groups showed different diversity and homogeneity, as well as distinct bacterial species. A more diverse and stable microbial population was observed among OPD patients. Our findings indicated that home-care patients had a higher risk of oral diseases due to the existence of dominant species and a less stable microbial community. Conclusion: This work was the first in Taiwan to use NGS to investigate the oral microbiota of long-term care patients. Our study demonstrated the potential use of dominant bacterial species as biomarkers for the risk management of posttreatment complications.

期刊Journal of Oral Microbiology
出版狀態Published - 2月 2022


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