Local hemostatic matrix for endoscope-assisted removal of intracerebral hemorrhage is safe and effective

Hui Tzung Luh, Abel Po Hao Huang, Shih Hung Yang, Chien Ming Chen, Der Yang Cho, Chun Chung Chen, Lu Ting Kuo, Chieh Hsun Li, Kuo Chuan Wang, Wei Lung Tseng, Ming Tai Hsing, Bing-Shiang Yang, Dar Ming Lai, Jui Chang Tsai*

*此作品的通信作者

研究成果: Article同行評審

16 引文 斯高帕斯(Scopus)

摘要

Background/Purpose: Minimally invasive endoscope-assisted (MIE) evacuation of spontaneous intracerebral hemorrhage (ICH) is simple and effective, but the limited working space may hinder meticulous hemostasis and might lead to rebleeding. Management of intraoperative hemorrhage is therefore a critical issue of this study. This study presents experience in the treatment of patients with various types of ICH by MIE evacuation followed by direct local injection of FloSeal Hemostatic Matrix (Baxter Healthcare Corp, Fremont, CA, USA) for hemostasis. Methods: The retrospective nonrandomized clinical and radiology-based analysis enrolled 42 patients treated with MIE evacuation of ICH followed by direct local injection of FloSeal Hemostatic Matrix. Rebleeding, morbidity, and mortality were the primary endpoints. The percentage of hematoma evacuated was calculated from the pre- and postoperative brain computed tomography (CT) scans. Extended Glasgow Outcome Scale (GOSE) was evaluated at 6 months postoperatively. Results: Forty-two ICH patients were included in this study, among these, 23 patients were putaminal hemorrhage, 16 were thalamic ICH, and the other three were subcortical type. Surgery-related mortality was 2.4%. The average percentage of hematoma evacuated was 80.8%, and the rebleeding rate was 4.8%. The mean operative time was 102.7 minutes and the average blood loss was 84.9 mL. The mean postoperative GOSE score was 4.55 at 6-months' follow-up. Conclusion: This study shows that local application of FloSeal Hemostatic Matrix is safe and effective for hemostasis during MIE evacuation of ICH. In our experience, this shortens the operation time, especially in cases with intraoperative bleeding. A large, prospective, randomized trial is needed to confirm the findings.

原文American English
頁(從 - 到)63-70
頁數8
期刊Journal of the Formosan Medical Association
117
發行號1
DOIs
出版狀態Published - 1月 2018

指紋

深入研究「Local hemostatic matrix for endoscope-assisted removal of intracerebral hemorrhage is safe and effective」主題。共同形成了獨特的指紋。

引用此