Litebamine N-homologues: Preparation and anti-acetylcholinesterase activity

Chi Ming Chiou; Jaw Jou Kang; Shoei Sheng Lee

doi:10.1021/np970298f

Litebamine N-homologues: Preparation and anti-acetylcholinesterase activity

Chi Ming Chiou, Jaw Jou Kang, Shoei Sheng Lee^*

^*此作品的通信作者

食品安全及健康風險評估研究所

研究成果: Article › 同行評審

42 引文斯高帕斯（Scopus）

摘要

Litebamine N-homologues were easily prepared from laurolitsine, generally via three reaction steps (N-alkylation, solvolysis with 1 M NH₄OAc under reflux, and the Mannich reaction) in more than 80% overall yield. Among the prepared compounds, N-propyl-, N-isobutyl-, and N-isopropylnorlitebamines exhibited moderate antiacetylcholinesterase activity (IC₅₀ ca. 7.0 μM), while the corresponding N-metho salt of N-propylnorlitebamine showed potent activity (IC₅₀ 2.70 μM).

原文	English
頁（從 - 到）	46-50
頁數	5
期刊	Journal of Natural Products
卷	61
發行號	1
DOIs	https://doi.org/10.1021/np970298f
出版狀態	Published - 1月 1998

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10.1021/np970298f

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abstract = "Litebamine N-homologues were easily prepared from laurolitsine, generally via three reaction steps (N-alkylation, solvolysis with 1 M NH4OAc under reflux, and the Mannich reaction) in more than 80% overall yield. Among the prepared compounds, N-propyl-, N-isobutyl-, and N-isopropylnorlitebamines exhibited moderate antiacetylcholinesterase activity (IC50 ca. 7.0 μM), while the corresponding N-metho salt of N-propylnorlitebamine showed potent activity (IC50 2.70 μM).",

author = "Chiou, {Chi Ming} and Kang, {Jaw Jou} and Lee, {Shoei Sheng}",

year = "1998",

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AB - Litebamine N-homologues were easily prepared from laurolitsine, generally via three reaction steps (N-alkylation, solvolysis with 1 M NH4OAc under reflux, and the Mannich reaction) in more than 80% overall yield. Among the prepared compounds, N-propyl-, N-isobutyl-, and N-isopropylnorlitebamines exhibited moderate antiacetylcholinesterase activity (IC50 ca. 7.0 μM), while the corresponding N-metho salt of N-propylnorlitebamine showed potent activity (IC50 2.70 μM).

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Litebamine N-homologues: Preparation and anti-acetylcholinesterase activity

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