摘要
A novel protocol for rapid assemble of benzimidazole framework has been demonstrated. This method incorporated with light fluorous-tag provides a convenient method for diversification of benzimidazoles and for easy purification via fluorous solid-phase extraction (F-SPE) in a parallel manner. The key transformation of this study involves in situ reduction of aromatic nitro compound, amide formation, cyclization and aromatization promoted by microwave irradiation in a one-pot fashion. The strategy is envisaged to be applied for the establishment of drug-like small molecule libraries for high throughput screening.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 411-417 |
| 頁數 | 7 |
| 期刊 | Combinatorial Chemistry and High Throughput Screening |
| 卷 | 15 |
| 發行號 | 5 |
| DOIs | |
| 出版狀態 | Published - 1 6月 2012 |