@article{4376a6209382453484542178e3cccf96,
title = "Investigation on native vesicles containing the nicotinic acetylcholine receptor using FTIR-spectroscopy",
abstract = "The ligand gated ion channel nicotinic acetylcholine receptor is responsible for the electrochemical signal transduction in nerve cells and at the motor endplates. In the recent years the structure of the channel has emerged to a resolution of 4.6 {\AA} [J. Mol. Biol. 288 (1999) 765]. We have used ATR-FTIR and SEIRA spectroscopy to investigate the extramembraneous structure of the receptor. The adsorption of nicotinic acetylcholine receptor rich vesicles on the surface of Ag-cluster leads to the detection of high content of helical structure in the extra membranous parts of the receptor. Spectra indicate a β-sheet structure perpendicular to the crystal plane.",
keywords = "FTIR-spectroscopy, Ion channel, nAChR, SEIRA spectroscopy",
author = "Fischer, {Wolfgang B.} and Gerald Steiner and Christian Kuhne and Reiner Salzer",
note = "Funding Information: The author wants to thank A. Maelicke und A. Schrattenholz (University of Mainz) for providing the nAChR rich vesicle suspensions. Thanks also to Dr. G. B{\"o}hme (Sentronic GmbH) for preparing the Ag coated Ge crystals for recording the IR spectra. This work was supported by the Bundesministerium f{\"u}r Bildung und Forschung.",
year = "2001",
month = aug,
day = "1",
doi = "10.1016/S0022-2860(01)00508-7",
language = "English",
volume = "570",
pages = "153--158",
journal = "Journal of Molecular Structure",
issn = "0022-2860",
publisher = "Elsevier",
number = "1-3",
}