TY - JOUR
T1 - Investigation of Viscoelasticity in the Relationship between Carotid Artery Blood Pressure and Distal Pulse Volume Waveforms
AU - Lee, Jongchan
AU - Ghasemi, Zahra
AU - Kim, Chang Sei
AU - Cheng, Hao Min
AU - Chen, Chen Huan
AU - Sung, Shih Hsien
AU - Mukkamala, Ramakrishna
AU - Hahn, Jin Oh
N1 - Publisher Copyright:
© 2013 IEEE.
PY - 2018/3
Y1 - 2018/3
N2 - We investigated the relationship between carotid artery blood pressure (BP) and distal pulse volume waveforms (PVRs) via subject-specific mathematical modeling. We conceived three physical models to define the relationship: a tube-load model augmented with a gain (TLG), Voigt (TLV), and standard linear solid (TLS) models. We compared these models using PVRs measured via BP cuffs at an upper arm and an ankle as well as carotid artery tonometry waveform collected from 133 subjects. At both upper arm and ankle, PVR was related to carotid artery tonometry by TLV and TLS models better than by TLG model; when root-mean-squared over all the subjects, the systolic and diastolic BP errors between measured carotid artery tonometry waveform and the one estimated from distal PVR reduced from 4.3 mmHg and 4.6 mmHg (TLG) to 1.1 mmHg and 1.0 mmHg (TLS) for the upper arm (p < 0.0167), and from 2.1 mmHg and 1.7 mmHg (TLG) to 2.1 mmHg and 1.5 mmHg (TLV) for the ankle. Further, TLV and TLS models exhibited superior Akaike's Information Criterion (AIC) in both locations than TLG model. However, the difference between TLG versus TLV and TLS models associated with the ankle was not large. Therefore, the relationship of central arterial BP to arm PVR arises from both wave reflection and viscoelasticity while the relationship to ankle PVR mainly arises from wave reflection. These findings may imply that an effective subject-specific transfer function for estimating accurate central arterial BP from an arm PVR should account for the impact of viscoelasticity.
AB - We investigated the relationship between carotid artery blood pressure (BP) and distal pulse volume waveforms (PVRs) via subject-specific mathematical modeling. We conceived three physical models to define the relationship: a tube-load model augmented with a gain (TLG), Voigt (TLV), and standard linear solid (TLS) models. We compared these models using PVRs measured via BP cuffs at an upper arm and an ankle as well as carotid artery tonometry waveform collected from 133 subjects. At both upper arm and ankle, PVR was related to carotid artery tonometry by TLV and TLS models better than by TLG model; when root-mean-squared over all the subjects, the systolic and diastolic BP errors between measured carotid artery tonometry waveform and the one estimated from distal PVR reduced from 4.3 mmHg and 4.6 mmHg (TLG) to 1.1 mmHg and 1.0 mmHg (TLS) for the upper arm (p < 0.0167), and from 2.1 mmHg and 1.7 mmHg (TLG) to 2.1 mmHg and 1.5 mmHg (TLV) for the ankle. Further, TLV and TLS models exhibited superior Akaike's Information Criterion (AIC) in both locations than TLG model. However, the difference between TLG versus TLV and TLS models associated with the ankle was not large. Therefore, the relationship of central arterial BP to arm PVR arises from both wave reflection and viscoelasticity while the relationship to ankle PVR mainly arises from wave reflection. These findings may imply that an effective subject-specific transfer function for estimating accurate central arterial BP from an arm PVR should account for the impact of viscoelasticity.
KW - Arterial blood pressure
KW - central arterial blood pressure
KW - mathematical modeling
KW - pulse volume waveform
KW - transfer function
KW - tube-load model
KW - viscoelastic model
UR - http://www.scopus.com/inward/record.url?scp=85043286790&partnerID=8YFLogxK
U2 - 10.1109/JBHI.2017.2672899
DO - 10.1109/JBHI.2017.2672899
M3 - Article
C2 - 28237937
AN - SCOPUS:85043286790
SN - 2168-2194
VL - 22
SP - 460
EP - 470
JO - IEEE Journal of Biomedical and Health Informatics
JF - IEEE Journal of Biomedical and Health Informatics
IS - 2
ER -