Investigation of differences on cortical connectivity between patients with major depressive disorder and normal subjects using mr diffusion tensor imaging

Chia Feng Lu*, Shin Teng, Yu Te Wu, Po Shan Wang, Tze Chen Yeh, Tung Ping Su, Jen Chuen Hsieh

*此作品的通信作者

研究成果: Conference contribution同行評審

1 引文 斯高帕斯(Scopus)

摘要

Functional and structural neuroimaging studies of major depression disorder (MDD) have identified neurophysiologic abnormalities in multiple areas of the prefrontal cortex, the insula, the amygdale and the related parts of the striatum and thalamus. The functional knowledge of MDD was mainly obtained from the fMRI and PET studies, which reveal the local differences in blood oxygenation and metabolism of the specific neurotransmitters, respectively. For the structural studies, the T1-based and DTI (diffusion tensor image)-based studies, which defined the abnormalities in cortical thickness and the integrity of the white matter, respectively, were commonly used. However, most of these studies only addressed the local differences compared to the normal subjects and were limited to provide the overall associations of the cortical connectivity within the patient group. In this study, we employed the DTI-based fiber bundle tracking technique along with the graph theoretical analysis to investigate the difference of cortical connectivity between the patients with MDD and the normal group from both the global (mean properties for all regions) and local (region-by-region) aspects. Out results concluded that: 1) there were no globally but locally significant difference between two groups, specifically, the increase of the local connectivity in parietal and occipital lobes to compensate the decrease of the connectivity in frontal and temporal lobe; 2) the connection strength from left insula to left superior temporal pole was stronger in normal group than that in MDD group; 3) the connection strengths from left putamen to left triangular inferior frontal gyrus and left precuneus, were stronger in patient group than that in normal group.

原文English
主出版物標題ICBBT 2010 - 2010 International Conference on Bioinformatics and Biomedical Technology
頁面79-83
頁數5
DOIs
出版狀態Published - 2010
事件2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010 - Chengdu, China
持續時間: 16 4月 201018 4月 2010

出版系列

名字ICBBT 2010 - 2010 International Conference on Bioinformatics and Biomedical Technology

Conference

Conference2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010
國家/地區China
城市Chengdu
期間16/04/1018/04/10

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