@article{4d4a5b6dbb0b4e4ab13f8e563f3e0623,
title = "Intrastriatal transplantation of Sertoli cells may improve amphetamine- induced rotation and tyrosine hydroxylase immunoreactivity of the striatum in hemiparkinsonian rats",
abstract = "This study investigated survival and neurotrophic effects of Sertoli cells transplanted in the striatum of 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian rats. Primary cultures of Sertoli cells were established from 3-week old rats and characterized by associated marker, placental cadherin (P-cadherin). Two months after transplantation, amphetamine-induced rotations of rats transplanted with Sertoli cells were significantly lower than those of control rats. However, restoration of tyrosine hydroxylase (TH) immunoreactivity and Sertoli cells that expressed P-cadherin were only found in the striatum of the rat that showed full recovery from amphetamine-induced rotation 3 months after transplantation without immunosuppression. These results suggest that Sertoli cells transplanted in striatum of hemiparkinsonian rats may survive for at least 3 months, and improve amphetamine-induced rotation and restore TH immunoreactivity.",
keywords = "Parkinson's disease, Sertoli cell, Striatum, Substantia nigra, Transplantation",
author = "Liu, {Hwan Wun} and Kuang, {Ya Jane} and Wu, {Jiahn Chun} and Ma, {Kuo Hsing} and Wang, {Shwun De} and Liu, {Jiang Chuan}",
note = "Funding Information: Authors are grateful to Professor Marion Murray of Department of Neurobiology and Anatomy, Allegheny University of the Health Sciences, Philadelphia, PA, and Dr. Cesario V. Borlongan of Cellular Neurophysiology Section, National Institute on Drug Abuse, Baltimore, MD, USA, for their generous help in preparing this paper. This study is supported by grants (NSC 86-2314-B016-066-M20 and NSC 87-2314-B016-066-M20) from National Science Council of Republic of China. ",
year = "1999",
month = aug,
day = "14",
doi = "10.1016/S0006-8993(99)01656-X",
language = "English",
volume = "838",
pages = "227--233",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",
}