Interplay of immunometabolism and epithelial–mesenchymal transition in the tumor microenvironment

Ming Yu Chou, Muh Hwa Yang*

*此作品的通信作者

研究成果: Review article同行評審

14 引文 斯高帕斯(Scopus)

摘要

Epithelial–mesenchymal transition (EMT) and metabolic reprogramming in cancer cells are the key hallmarks of tumor metastasis. Since the relationship between the two has been well studied, researchers have gained increasing interest in the interplay of cancer cell EMT and immune metabolic changes. Whether the mutual influences between them could provide novel explanations for immune surveillance during metastasis is worth understanding. Here, we review the role of immunometabolism in the regulatory loop between tumor-infiltrating immune cells and EMT. We also discuss the challenges and perspectives of targeting immunometabolism in cancer treatment.

原文English
文章編號9878
期刊International Journal Of Molecular Sciences
22
發行號18
DOIs
出版狀態Published - 9月 2021

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