Integrated multiple multi-photon imaging and Raman spectroscopy for characterizing structure-constituent correlation of tissues

Jhen Wei Jhan, Wei Tien Chang, Hung Che Chen, Yu Tsung Lee, Ming Fang Wu, Chung Hsuan Chen, Ian Liau*

*此作品的通信作者

研究成果: Article同行評審

22 引文 斯高帕斯(Scopus)

摘要

Histopathological imaging of tissues often requires extensive sample preparation including fixation and staining in order to highlight characteristic alterations associated with diseases. Herein, we report an integrated spectro-microscopy approach based on a combination of multi-modal multi-photon imaging and Raman micro-spectroscopy and demonstrate label-free characterization of the structure-constituent correlation of porcine skin. The multi-modal imaging allows the visualization of dermatological features whereas Raman micro-spectroscopy enables the identification of their 'molecular fingerprints'. By obtaining both structural and molecular-level information of tissue constituents, this integrated approach can offer new insight into the patho-physiological status of tissues.

原文English
頁(從 - 到)16431-16441
頁數11
期刊Optics Express
16
發行號21
DOIs
出版狀態Published - 13 10月 2008

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