TY - JOUR
T1 - Inflammation, kidney function and albuminuria in the Framingham Offspring cohort
AU - Upadhyay, Ashish
AU - Larson, Martin G.
AU - Guo, Chao Yu
AU - Vasan, Ramachandran S.
AU - Lipinska, Izabella
AU - O'Donnell, Christopher J.
AU - Kathiresan, Sekar
AU - Meigs, James B.
AU - Keaney, John F.
AU - Rong, Jian
AU - Benjamin, Emelia J.
AU - Fox, Caroline S.
N1 - Funding Information:
Support: The Framingham Heart Study is supported by the National Heart, Lung and Blood Institute grant N01-HC-25195. Additional funding provided by the National Institute of Health’s grants R01-HL70139 and R01-Hl04334 for R.S.V., R01-HL-64753 and R01-HL-076784 AG028321 for E.J.B., and the American Diabetes Association research grant and the National Institute of Diabetes and Digestive and Kidney Diseases grant K24-DK080140 for J.B.M.
PY - 2011/3
Y1 - 2011/3
N2 - Background: Inflammation and chronic kidney disease (CKD) are both associated with cardiovascular disease (CVD). Whether inflammatory biomarkers are associated with kidney function and albuminuria after accounting for traditional CVD risk factors is not completely understood.Methods. The sample comprised Framingham Offspring cohort participants (n = 3294, mean age 61, 53% women) who attended the seventh examination cycle (19982001). Inflammatory biomarkers [C-reactive protein (CRP), tumour necrosis factor (TNF)-alpha, interleukin-6, TNF receptor 2 (TNFR2), intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1), P-selectin, CD-40 ligand, osteoprotegerin, urinary isoprostanes, myeloperoxidase and fibrinogen] were measured on fasting blood samples. Serum creatinine-based estimated glomerular filtration rate (eGFR) and serum cystatin C concentration were used to assess kidney function. Urinary albumin-to-creatinine ratio (UACR) was used to assess albuminuria. Linear or logistic regression was used to test associations between biomarkers and kidney measures.Results. Chronic kidney disease (CKD), defined as eGFR < 59/64 mL/min/1.73 m2 in women/men, was present in 8.8% (n = 291) of participants. TNF-alpha, interleukin-6, TNFR2, MCP-1, osteoprotegerin, myeloperoxidase and fibrinogen were higher among individuals with CKD; all biomarkers except for urinary isoprostanes were elevated in higher cystatin C quartiles; and TNF-alpha, interleukin-6, TNFR2, ICAM-1 and osteoprotegerin were elevated in higher UACR quartilesall assessed after multivariable adjustment. Almost 6% and 17% of variability in TNFR2 were explained by CKD status and higher cystatin C quartiles, respectively. Conclusions. Biomarkers of inflammation are associated with kidney function and albuminuria. In particular, substantial variability in soluble TNFR2 is explained by CKD and cystatin C.
AB - Background: Inflammation and chronic kidney disease (CKD) are both associated with cardiovascular disease (CVD). Whether inflammatory biomarkers are associated with kidney function and albuminuria after accounting for traditional CVD risk factors is not completely understood.Methods. The sample comprised Framingham Offspring cohort participants (n = 3294, mean age 61, 53% women) who attended the seventh examination cycle (19982001). Inflammatory biomarkers [C-reactive protein (CRP), tumour necrosis factor (TNF)-alpha, interleukin-6, TNF receptor 2 (TNFR2), intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1), P-selectin, CD-40 ligand, osteoprotegerin, urinary isoprostanes, myeloperoxidase and fibrinogen] were measured on fasting blood samples. Serum creatinine-based estimated glomerular filtration rate (eGFR) and serum cystatin C concentration were used to assess kidney function. Urinary albumin-to-creatinine ratio (UACR) was used to assess albuminuria. Linear or logistic regression was used to test associations between biomarkers and kidney measures.Results. Chronic kidney disease (CKD), defined as eGFR < 59/64 mL/min/1.73 m2 in women/men, was present in 8.8% (n = 291) of participants. TNF-alpha, interleukin-6, TNFR2, MCP-1, osteoprotegerin, myeloperoxidase and fibrinogen were higher among individuals with CKD; all biomarkers except for urinary isoprostanes were elevated in higher cystatin C quartiles; and TNF-alpha, interleukin-6, TNFR2, ICAM-1 and osteoprotegerin were elevated in higher UACR quartilesall assessed after multivariable adjustment. Almost 6% and 17% of variability in TNFR2 were explained by CKD status and higher cystatin C quartiles, respectively. Conclusions. Biomarkers of inflammation are associated with kidney function and albuminuria. In particular, substantial variability in soluble TNFR2 is explained by CKD and cystatin C.
KW - C-reactive protein
KW - albuminuria
KW - chronic kidney disease
KW - inflammation
UR - http://www.scopus.com/inward/record.url?scp=79952144836&partnerID=8YFLogxK
U2 - 10.1093/ndt/gfq471
DO - 10.1093/ndt/gfq471
M3 - Article
C2 - 20682604
AN - SCOPUS:79952144836
SN - 0931-0509
VL - 26
SP - 920
EP - 926
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
IS - 3
ER -
