Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: A role for TNF-R1 activation by endogenous membrane-anchored TNF

Matthias Grell*, Gudrun Zimmermann, Eva Gottfried, Chun Ming Chen, Uli Grünwald, David C.S. Huang, Yan-Hwa Wu Lee, Horst Dürkop, Hartmut Engelmann, Peter Scheurich, Harald Wajant, Andreas Strasser

*此作品的通信作者

研究成果: Article同行評審

259 引文 斯高帕斯(Scopus)

摘要

Several members of the tumour necrosis factor receptor (TNF-R) superfamily can induce cell death. For TNF-R1, Fas/APO-1, DR3, DR6, TRAIL-R1 and TRAIL-R2, a conserved 'death domain' in the intracellular region couples these receptors to activation of caspases. However, it is not yet known how TNF receptor family members lacking a death domain, such as TNF-R2, CD40, LT-βR, CD27 or CD30, execute their death-inducing capability. Here we demonstrate in different cellular systems that cytotoxic effects induced by TNF-R2, CD40 and CD30 are mediated by endogenous production of TNF and autotropic or paratropic activation of TNF-R1. In addition, stimulation of TNF-R2 and CD40 synergistically enhances TNF-R1-induced cytotoxicity. These findings describe a novel pro-apoptotic mechanism induced by some members of the TNF-R family.

原文English
頁(從 - 到)3034-3043
頁數10
期刊EMBO Journal
18
發行號11
DOIs
出版狀態Published - 1 6月 1999

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