In vitro activities of doripenem and other carbapenems against clinically important bacteria isolated in intensive care units: Nationwide data from the SMART Programme

S. S. Jean, P. R. Hsueh*, W. S. Lee, H. T. Chang, M. Y. Chou, I. S. Chen, J. H. Wang, C. F. Lin, J. M. Shyr, W. C. Ko, J. J. Wu, Y. C. Liu, W. K. Huang, L. J. Teng, C. Y. Liu

*此作品的通信作者

研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)

摘要

This nationwide surveillance of clinically important bacteria from the intensive care units (ICUs) of major teaching hospitals throughout Taiwan investigated the susceptibilities to doripenem and other comparator carbapenems from September through November 2005. Minimum inhibitory concentrations (MICs) were determined for 1,311 clinical isolates using the broth microdilution method according to Clinical and Laboratory Standards Institute (CLSI) 2005 guidelines. Doripenem showed similar (within four-fold difference of MICs) in vitro activity to meropenem for Enterobacteriaceae and probably comparable activity to meropenem against important nosocomial non-fermentative Gram-negative bacilli (NFGNBs), including Pseudomonas aeruginosa, Acinetobacter baumannii and Burkholderia cepacia. Among the four carbapenems analysed, doripenem and meropenem exhibited better in vitro activity than imipenem or ertapenem against extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli isolates. However, the meropenem MIC 90 against ESBL-producing K. pneumoniae isolates was 2 μg/ml. Besides, doripenem with the MIC90 of 0.5 μg/ml to Streptococcus pneumoniae possibly suggested its potential therapeutic effect regarding community-acquired pneumonia. Because of the heavy resistance burden in Taiwan, closely monitoring the evolutionary trend of carbapenem susceptibilities against clinically important pathogens is crucial in the future.

原文English
頁(從 - 到)471-475
頁數5
期刊European Journal of Clinical Microbiology and Infectious Diseases
29
發行號4
DOIs
出版狀態Published - 4月 2010

指紋

深入研究「In vitro activities of doripenem and other carbapenems against clinically important bacteria isolated in intensive care units: Nationwide data from the SMART Programme」主題。共同形成了獨特的指紋。

引用此