Improving the Diagnostic Performance by Adding Methylation Marker to Conventional Visual Examination in Identifying Oral Cancer

Cheng Chieh Yang, Yee Fun Su, Han Chieh Cheng, Yi Chen Juan, Yu Wei Chiu, Cheng Hsien Wu, Pei Yin Chen, Yu Hsien Lee, Yen Lin Chen, Yi Tzu Chen, Chih Yu Peng, Ming Yi Lu, Chuan Hang Yu, Yu Feng Huang, Shou Yen Kao, Chyng Wen Fwu*, Chung Ji Liu

*此作品的通信作者

研究成果: Article同行評審

摘要

Background: Visual oral examination (VOE) is a conventional oral cancer screening method. This study aimed to evaluate the value of methylation marker to assist VOE in identifying oral epithelial dysplasia and oral squamous cell carcinoma (OED/OSCC) from non‐cancerous lesions in a real‐world situation. Methods: 201 patients with high‐risk personal habits who self‐perceived oral anomaly were VOE examined, ZNF582 methylation (ZNF582m) tested, and histologically diagnosed. Results: Among them, 132 patients (65.7%) were histologically diagnosed OED/OSCC. Using VOE, 56.1% OED/OSCC patients had possible oral cancer, whereas 37.7% non‐OED/OSCC patients had leukoplakia. ZNF582m‐positive was detected in 90.2% OED/OSCC patients and 44.9% non‐OED/OSCC patients. Various logistic regression models were postulated to evaluate the diagnostic performance of conventional VOE and new strategies using ZNF582m. ROC analysis and its corresponding C‐index demonstrated that either triage or co‐testing models of VOE and ZNF582m could improve diagnostic performance and discriminative abilities compared with the VOE only approach. Conclusions: In conclusion, methylation marker test shows equivalent performance to an experienced judgment by oral maxillofacial surgeons and plays a significantly supplementary role in increasing the efficacy in identifying oral malignant lesions. ZNF582m may be an especially important tool for family physicians or general dentists to properly diagnose suspicious oral lesions.

原文English
文章編號1544
期刊Diagnostics
12
發行號7
DOIs
出版狀態Published - 7月 2022

指紋

深入研究「Improving the Diagnostic Performance by Adding Methylation Marker to Conventional Visual Examination in Identifying Oral Cancer」主題。共同形成了獨特的指紋。

引用此