Immune responses to guided imagery during breast cancer treatment

Cecile A. Lengacher*, Mary P. Bennett, Lois Gonzalez, Danielle Gilvary, Charles E. Cox, Alan Cantor, Paul B. Jacobsen, Chiu Yang, Julie Djeu



18 引文 斯高帕斯(Scopus)


Background: The use of relaxation and guided imagery to reduce stress and improve immune function has great potential benefits for patients with breast cancer. Methods: This pilot study used a pretest-posttest experimental design with 28 breast cancer patients, aged 25 to 75 years, with the diagnosis of stage 0, 1, or 2 breast cancer. The experimental group received a relaxation and guided imagery intervention and the control group received standard care. The effects of the intervention on immune function were measured by natural killer (NK) cell cytotoxicity and IL-2-activated NK cell activity prior to surgery and 4 weeks postsurgery. NK cell activity was measured using a 15-hr incubation chromium release assay. Cytotoxicity of NK cells was measured against chromium-labeled K-562 target cells. IL-2 was used to enhance reactivity of NK cells against tumor cells. After incubation for 15 hr, cytotoxicity was measured through the release of radioactive chromium. Results: Significant differences between groups were found at 4 weeks postsurgery. T-tests showed increased NK cell cytotoxicity for the intervention group at 100:1, 50:1, and 25:1 effector cell: target cell ratios (E:T) (p <.01 to p <.05) and increased activation for IL-2 at 100:1, 50:1, 25:1, and 12.5:1 (E:T) (p <.01 to p <.05) for the intervention group as compared to the control group. Discussion: These findings suggest that a relaxation intervention such as guided imagery could have an effect on NK cell cytotoxicity and NK cell cytotoxicity after activation with IL-2 in patients undergoing surgery for breast cancer.

頁(從 - 到)205-214
期刊Biological Research for Nursing
出版狀態Published - 1月 2008


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