Immune Adaptation of Colorectal Cancer Stem Cells and Their Interaction With the Tumor Microenvironment

Chun Chi Lin, Tsai Tsen Liao, Muh Hwa Yang*

*此作品的通信作者

研究成果: Review article同行評審

17 引文 斯高帕斯(Scopus)

摘要

Metastasis is the primary cause of death in colorectal cancer (CRC) patients. Emerging evidence has shown that CRC stem cells (CRCSCs) play a significant role in metastatic dissemination and tumor recurrence. However, strategies for targeting CRCSCs are limited because CRCSCs are resistant to therapeutic interventions and because the tumor microenvironment (TME) provides a supportive niche. Moreover, growing evidence highlights the critical role of CRCSCs in immune adaptation and modulation of the TME. CRCSCs escape immune surveillance by avoiding recognition by the innate immune system and shaping the TME through exosomes, cytokines, and chemokines to generate an immunosuppressive niche that facilitates cancer progression. In this review, we summarize studies investigating the immunomodulatory properties of CRCSCs and their underlying mechanisms in order to improve the efficacy of treatment strategies against advanced CRC.

原文English
文章編號588542
期刊Frontiers in Oncology
10
DOIs
出版狀態Published - 18 11月 2020

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