Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein

Lih Hwa Hwang, Pei Ming Yang, Ming Yang Lai, Bor Luen Chiang, Jia Horng Kao, Jin Town Wang, Shiau Yuan Lee, Huei Min Chian, Wei Kuang Chi, Yi Ding Chu, Pei Jer Chen, Ding Shinn Chen*

*此作品的通信作者

研究成果: Article同行評審

13 引文 斯高帕斯(Scopus)

摘要

Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa 1250/1251), A (within aa 1250- 1334), A/B (around aa 1323 and 1334), and B/C (around aa 1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis (10% vs. 46%, χ2 = 12.05. P < .01). The results suggest that region A might be a potential prognostic marker to differentiate chronic hepatitis from cirrhosis.

原文English
頁(從 - 到)173-176
頁數4
期刊Journal of Infectious Diseases
174
發行號1
DOIs
出版狀態Published - 1996

指紋

深入研究「Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein」主題。共同形成了獨特的指紋。

引用此