Hyperthermia induced by near-infrared laser-irradiated CsWO3 nanoparticles disintegrates preformed lysozyme amyloid fibrils

Po Sheng Hu*, Natalia Tomasovicova, Hsiu Jen Chou, Meng Chang Li, Marek Vojtko, Katarina Zakutanska, Jozefina Majorosova, Shean Jen Chen, Peter Kopcansky

*此作品的通信作者

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    摘要

    This research study attempts to prove the concept of the applicability of hyperthermia to treating the lysozyme amyloid fibrils (LAF)’s self-assembled fibrillary aggregates by a feedback-modulated temperature controller ranging from 26 °C to 80 °C, and separately, by near-infrared (NIR) laser-irradiated cesium tungstate (CsWO3) nanoparticle (NPs). The dependence of the final morphology of the amyloidal assembly on external heating and the photothermal effect of the NPs on treating the fibrillary assembly were investigated and analyzed. Experimentally, atomic force microscopy (AFM), optical stereoscopy, and scanning electron microscopy (SEM) were used primarily to ensure mutual interaction between LAF and NPs, optically elucidate the surface contour and final fibrillary assembly upon the influence of thermal treatment, and further reveal fine-details of the optical samples. Finally, conclusive remarks are drawn that the fibrillary structures doped with the NPs exhibit an increasing degree of unique orthogonality. As the temperature rises, utter deformation of the dendritic structures of fibrillary assemblies at 70 °C was found, and NIR laser-irradiated CsWO3 NPs have been demonstrated to be useful in topically destructing pre-assembled LAFs, which may be conducive to the future development of neurodegenerative therapeutic techniques.

    原文English
    文章編號442
    期刊Nanomaterials
    10
    發行號3
    DOIs
    出版狀態Published - 三月 2020

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