Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection

Sheng Fan Wang; Kuan Hsuan Chen; Marcelo Chen; Wen Yi Li; Yen Ju Chen; Ching Han Tsao; Muh Yong Yen; Jason C. Huang; Yi Ming Arthur Chen

doi:10.1089/vim.2011.0024

Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection

Sheng Fan Wang, Kuan Hsuan Chen, Marcelo Chen, Wen Yi Li, Yen Ju Chen, Ching Han Tsao, Muh Yong Yen, Jason C. Huang, Yi Ming Arthur Chen^*

^*此作品的通信作者

研究成果: Article › 同行評審

107 引文斯高帕斯（Scopus）

摘要

One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).

原文	English
頁（從 - 到）	421-426
頁數	6
期刊	Viral Immunology
卷	24
發行號	5
DOIs	https://doi.org/10.1089/vim.2011.0024
出版狀態	Published - 1 10月 2011

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10.1089/vim.2011.0024

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title = "Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection",

abstract = "One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).",

author = "Wang, {Sheng Fan} and Chen, {Kuan Hsuan} and Marcelo Chen and Li, {Wen Yi} and Chen, {Yen Ju} and Tsao, {Ching Han} and Yen, {Muh Yong} and Huang, {Jason C.} and Chen, {Yi Ming Arthur}",

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doi = "10.1089/vim.2011.0024",

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T1 - Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection

AU - Wang, Sheng Fan

AU - Chen, Kuan Hsuan

AU - Chen, Marcelo

AU - Li, Wen Yi

AU - Chen, Yen Ju

AU - Tsao, Ching Han

AU - Yen, Muh Yong

AU - Huang, Jason C.

AU - Chen, Yi Ming Arthur

PY - 2011/10/1

Y1 - 2011/10/1

N2 - One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).

AB - One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).

UR - http://www.scopus.com/inward/record.url?scp=80054733924&partnerID=8YFLogxK

U2 - 10.1089/vim.2011.0024

DO - 10.1089/vim.2011.0024

M3 - Article

C2 - 21958371

AN - SCOPUS:80054733924

SN - 0882-8245

VL - 24

SP - 421

EP - 426

JO - Viral Immunology

JF - Viral Immunology

IS - 5

ER -

Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection

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