Host Lipid Rafts as the Gates for Listeria monocytogenes Infection: A Mini-Review

Yu Huan Tsai*, Wei Lin Chen

*此作品的通信作者

研究成果: Review article同行評審

9 引文 斯高帕斯(Scopus)

摘要

Listeria monocytogenes is a Gram-positive foodborne bacterial pathogen capable of interacting and crossing the intestinal barrier, blood–brain barrier, and placental barrier to cause deadly infection with high mortality. L. monocytogenes is an intracellular pathogen characterized by its ability to enter non-phagocytic cells. Expression of the cytolysin listeriolysin O has been shown to be the main virulence determinant in vitro and in vivo in mouse models. L. monocytogenes can also perform cell-to-cell spreading using actin-rich membrane protrusions to infect neighboring cells, which also constitutes an important strategy for infection. These events including entry into host cells, interaction between listeriolysin O and host plasma membrane, and bacterial cell-to-cell spreading have been demonstrated to implicate the cholesterol-rich lipid rafts or molecules in these microdomains in the host plasma membrane in vitro with tissue culture models. Here we review the contribution of lipid rafts on plasma membrane to L. monocytogenes infection.

原文English
文章編號1666
期刊Frontiers in Immunology
11
DOIs
出版狀態Published - 11 8月 2020

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