Highly Sensitive and Selective Detection of Melatonin in Biofluids by Antipyrine Based Fluorophore

Sathya Vijayakumar, Srinivasadesikan Venkatesan, Ming Chang Lin, Padmini Vediappen*

*此作品的通信作者

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

A simple fluorescent based organic fluorophore was synthesized and it shows significant fluorescent intensity with melatonin (MLN). Hence, it was applicable to the detection of MLN by colorimetric and fluorimetric techniques at neutral pH. Under optimized experimental condition, the synthesized organic fluorophore detects MLN selectively in the presence of other interfering biomolecules through ICT mechanism. The melatonin sensing mechanism is supported by DFT and 1H-NMR titration. Based on the findings, this method can be applied to design a simple clinical diagnostic tool for MLN. Graphical Abstract: [Figure not available: see fulltext.].

原文English
頁(從 - 到)383-392
頁數10
期刊Journal of Fluorescence
33
發行號1
DOIs
出版狀態Published - 1月 2023

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