TY - JOUR
T1 - Highly selective detection of citrulline using curcumin analogue and its application in food samples with logic gate behaviour
AU - Lavanya, Raja
AU - Srinivasadesikan, Venkatesan
AU - Lin, Ming chang
AU - Padmini, Vediappen
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/9/15
Y1 - 2023/9/15
N2 - A new curcumin-based biosensor (E)-5-(4-hydroxyphenyl)-1-phenylpent-4-ene-1,3‑dione (5HPD) was successfully synthesized for the selective detection of citrulline (Cit). Job's plot analysis indicated, a 1:1 binding stoichiometry between the sensor (5HPD) and citrulline. The binding constant was estimated to be 3.55 × 107 M−1 according to the Stern Volmer method. The newly synthesized sensor 5HPD is highly selective detection towards citrulline with various competitive biomolecules. Linearity ranges of 10 - 60 μM and lower detection limits is 75 nM. Interestingly, a reversible process provoke successively by 5HPD, Cit with EDTA observed and molecular logic circuits. The Mechanism of sensing 5HPD-Cit has been characterized clearly by 1H NMR, FTIR, ESI-MS spectroscopy and DFT calculation.
AB - A new curcumin-based biosensor (E)-5-(4-hydroxyphenyl)-1-phenylpent-4-ene-1,3‑dione (5HPD) was successfully synthesized for the selective detection of citrulline (Cit). Job's plot analysis indicated, a 1:1 binding stoichiometry between the sensor (5HPD) and citrulline. The binding constant was estimated to be 3.55 × 107 M−1 according to the Stern Volmer method. The newly synthesized sensor 5HPD is highly selective detection towards citrulline with various competitive biomolecules. Linearity ranges of 10 - 60 μM and lower detection limits is 75 nM. Interestingly, a reversible process provoke successively by 5HPD, Cit with EDTA observed and molecular logic circuits. The Mechanism of sensing 5HPD-Cit has been characterized clearly by 1H NMR, FTIR, ESI-MS spectroscopy and DFT calculation.
KW - Biomolecules
KW - Citrulline
KW - Curcumin
KW - EDTA and DFT calculation
KW - Lower detection limit
UR - http://www.scopus.com/inward/record.url?scp=85162230840&partnerID=8YFLogxK
U2 - 10.1016/j.molstruc.2023.135771
DO - 10.1016/j.molstruc.2023.135771
M3 - Review article
AN - SCOPUS:85162230840
SN - 0022-2860
VL - 1288
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
M1 - 135771
ER -