Tougher, lighter, and more formable and machinable metals for broader ranges of applications at higher temperatures are needed now more than ever. High-performance computing, high-resolution microscopy, and advanced spectroscopy methods, including neutrons and synchrotron x-rays, together with advances in metallurgy and metal mixology, reveal the potential of multicomponent advanced metals, such as multicomponent bulk metallic glasses and advanced high-entropy alloys. The development of new experimental approaches relates bulk properties and voxel-associated optimized properties throughout structures with high resolution. The correlations from in situ measurements greatly improve crystal plasticity-based models. This issue of MRS Bulletin overviews recent progress in the field, and this article highlights the importance of these new perspectives. The latest progress and directions in the science and technology for prospective high-temperature metals for structural applications are reported.