High sensitivity CIP2A detection for oral cancer using a rapid transistor-based biosensor module

Minghan Xian, Jenna L. Stephany, Chan Wen Chiu, Chao Ching Chiang, Fan Ren, Cheng Tse Tsai, Siang Sin Shan, Yu Te Liao, Josephine F. Esquivel-Upshaw, Stephen J. Pearton

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Oral squamous cell carcinoma (OSCC) is one of the most common lip and oral cavity cancer types. It requires early detection via various medical technologies to improve the survival rate. While most detection techniques for OSCC require testing in a centralized lab to confirm cancer type, a point of care detection technique is preferred for on-site use and quick result readout. The modular biological sensor utilizing transistor-based technology has been leveraged for testing CIP2A, and optimal transistor gate voltage and load resistance for sensing setup was investigated. Sensitivities of 1 × 10-15 g/ml have been obtained for both detections of pure CIP2A protein and HeLa cell lysate using identical test conditions via serial dilution. The superior time-saving and high accuracy testing provides opportunities for rapid clinical diagnosis in the medical space.

原文English
文章編號013201
期刊Journal of Vacuum Science and Technology B:Nanotechnology and Microelectronics
41
發行號1
DOIs
出版狀態Published - 1 1月 2023

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