HER2 immunohistochemical scores provide prognostic information for patients with HER2-type invasive breast cancer

Yi Fang Tsai, Ling Ming Tseng, Pei Ju Lien, Chih Yi Hsu*, Yen Shu Lin, Kuang Liang King, Yu Ling Wang, Ta Chung Chao, Chun Yu Liu, Jen Hwey Chiu, Muh Hwa Yang

*此作品的通信作者

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Aims: Invasive breast cancer patients with human epidermal growth factor receptor 2 (HER2) immunohistochemical (IHC) scores of 3+ or 2+ with reflex in-situ hybridisation (ISH) positivity are suitable for anti-HER2 therapies. The aim of this study is to investigate whether the prognoses between IHC 3+ patients and IHC 2+/ISH+ patients are different. Methods and results: We analysed the clinicopathological information of 886 consecutive cases of HER2-positive early breast cancer. The influences of the patients’ age, cancer stage, hormone receptor status and anti-HER2 treatment were adjusted using a multivariate Cox regression model. Both HER2 copy numbers and HER2 ISH ratios of the IHC 3+ group were significantly higher than those of the IHC 2+/ISH+ group. The outcomes of IHC 3+ patients were significantly better than those of IHC 2+/ISH+ patients in the univariate and multivariate analyses. HER2 copy numbers of ≥8 represented the best prognostic value, and it was chosen to be the cut-off value. The reflex ISH for IHC 2+ patients with high HER2 copy numbers (≥8) predicted a better overall survival than that for those with low HER2 copy numbers. Conclusion: HER2 IHC scores and HER2 copy numbers can provide prognostic information for patients with HER2-positive invasive breast cancer. Both IHC 3+ and IHC 2+ patients with high HER2 copy numbers had a better prognosis.

原文English
頁(從 - 到)578-586
頁數9
期刊Histopathology
74
發行號4
DOIs
出版狀態Published - 3月 2019

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