TY - JOUR
T1 - Hepatoprotection of noni juice against chronic alcohol consumption
T2 - Lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation
AU - Chang, Yuan Yen
AU - Lin, Yi Ling
AU - Yang, Deng Jye
AU - Liu, Chen Wei
AU - Hsu, Chin Lin
AU - Tzang, Bor Show
AU - Chen, Yi Chen
PY - 2013/11/20
Y1 - 2013/11/20
N2 - Chronic alcohol consumption leads to steatohepatitis and cirrhosis. Naturally fermented noni juice (NJ) contains polyphenols, polysaccharides, and some trace minerals. This study explored protective effects of NJ against chronic alcohol consumption. Mice were assigned randomly to one of the following groups: (1) control, control liquid diet and distilled water; (2) alcohol, alcohol liquid diet and distilled water; (3) Alc+NJ-1X, alcohol liquid diet and 5 mL NJ/kg BW; (4) Alc+NJ-2X, alcohol liquid diet and 10 mL NJ/kg BW; (5) Alc+NJ-3X, alcohol and 15 mL NJ/kg BW for 4 weeks. NJ decreased (p < 0.05) serum AST, ALT, and alcohol levels and liver lipids, as well as increased (p < 0.05) daily fecal lipid outputs in alcohol-diet fed mice. NJ supplementation not only down-regulated (p < 0.05) lipogenesis but also up-regulated (p < 0.05) fatty acid β-oxidation in livers of alcohol-diet fed mice. NJ also accelerated alcohol clearance via increased (p < 0.05) hepatic ADH and ALDH activities. NJ increased (p < 0.05) hepatic TEAC and GSH levels but decreased (p < 0.05) TBARS value and TLR2/4, P38, ERK 1/2, NFκB P65, iNOS, COX-2, TNF-α, and IL-1β expressions in alcohol-diet fed mice. NJ promotes hepatoprotection against alcohol-induced injury due to regulations of lipid homeostasis, antioxidant status, alcohol metabolism, and anti-inflammatory responses.
AB - Chronic alcohol consumption leads to steatohepatitis and cirrhosis. Naturally fermented noni juice (NJ) contains polyphenols, polysaccharides, and some trace minerals. This study explored protective effects of NJ against chronic alcohol consumption. Mice were assigned randomly to one of the following groups: (1) control, control liquid diet and distilled water; (2) alcohol, alcohol liquid diet and distilled water; (3) Alc+NJ-1X, alcohol liquid diet and 5 mL NJ/kg BW; (4) Alc+NJ-2X, alcohol liquid diet and 10 mL NJ/kg BW; (5) Alc+NJ-3X, alcohol and 15 mL NJ/kg BW for 4 weeks. NJ decreased (p < 0.05) serum AST, ALT, and alcohol levels and liver lipids, as well as increased (p < 0.05) daily fecal lipid outputs in alcohol-diet fed mice. NJ supplementation not only down-regulated (p < 0.05) lipogenesis but also up-regulated (p < 0.05) fatty acid β-oxidation in livers of alcohol-diet fed mice. NJ also accelerated alcohol clearance via increased (p < 0.05) hepatic ADH and ALDH activities. NJ increased (p < 0.05) hepatic TEAC and GSH levels but decreased (p < 0.05) TBARS value and TLR2/4, P38, ERK 1/2, NFκB P65, iNOS, COX-2, TNF-α, and IL-1β expressions in alcohol-diet fed mice. NJ promotes hepatoprotection against alcohol-induced injury due to regulations of lipid homeostasis, antioxidant status, alcohol metabolism, and anti-inflammatory responses.
KW - alcohol metabolism
KW - anti-inflammatory response
KW - antioxidant capacity
KW - lipid homeostasis
KW - noni juice
UR - http://www.scopus.com/inward/record.url?scp=84888367970&partnerID=8YFLogxK
U2 - 10.1021/jf4038419
DO - 10.1021/jf4038419
M3 - Article
C2 - 24152092
AN - SCOPUS:84888367970
SN - 0021-8561
VL - 61
SP - 11016
EP - 11024
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 46
ER -