Heart failure enhances arrhythmogenesis in pulmonary veins

Shih Lin Chang, Yao Chang Chen, Yung Hsin Yeh, Yu Jun Lai, Hung I. Yeh, Cheng I. Lin, Yung Kuo Lin, Yenn Jiang Lin, Tsu Juey Wu, Yi Kung Huang, Shih Ann Chen, Yi Jen Chen*


研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)


1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P<0.001) and high-frequency irregular electrical activity (92 vs 38%, P=0.01; 23±1 vs 19±1Hz, P=0.003), greater depolarized resting membrane potential (-59±1 vs -70±2mV, P<0.001), higher incidence of early afterdepolarizations (EAD; 69 vs 6%, P=0.001) and delayed afterdepolarizations (DAD; 92 vs 25%, P=0.001), and slower conduction velocity (38±2 vs 63±2cm/s, P<0.05). In comparison to the HF-LA, the HF-PV had a higher incidence of spontaneous activity and high-frequency irregular electrical activity (85 vs 39%, P=0.04; 92 vs 46%, P=0.03), and higher incidence of EAD and DAD, and those differences were not found between the control-LA and control-PV. The control-PV with high-frequency irregular electrical activity had a higher incidence of DAD and spontaneous activity as compared with those without it. 4.HF contributed to an increased automaticity, triggered activity and conduction disturbance in the PV. The PV possessed more arrhythmogenic properties, which might play an important role in the genesis of AF in HF.

頁(從 - 到)666-674
期刊Clinical and Experimental Pharmacology and Physiology
出版狀態Published - 10月 2011


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