TY - GEN
T1 - H&E Stain Normalization using U-Net
AU - Lee, Chi Chen
AU - Kuo, Po Tsun Paul
AU - Peng, Chi Han
N1 - Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - We propose a novel hematoxylin and eosin (H&E) stain normalization method based on a modified U-Net neural network architecture. Unlike previous deep-learning methods that were often based on generative adversarial networks (GANs), we take a teacher-student approach and use paired datasets generated by a trained CycleGAN to train a U-Net to perform the stain normalization task. Through experiments, we compared our method to two recent competing methods, CycleGAN and StainNet, a lightweight approach also based on the teacher-student model. We found that our method is faster and can process larger images with better quality compared to CycleGAN. We also compared to StainNet and found that our method delivered quantitatively and qualitatively better results.
AB - We propose a novel hematoxylin and eosin (H&E) stain normalization method based on a modified U-Net neural network architecture. Unlike previous deep-learning methods that were often based on generative adversarial networks (GANs), we take a teacher-student approach and use paired datasets generated by a trained CycleGAN to train a U-Net to perform the stain normalization task. Through experiments, we compared our method to two recent competing methods, CycleGAN and StainNet, a lightweight approach also based on the teacher-student model. We found that our method is faster and can process larger images with better quality compared to CycleGAN. We also compared to StainNet and found that our method delivered quantitatively and qualitatively better results.
UR - http://www.scopus.com/inward/record.url?scp=85145597188&partnerID=8YFLogxK
U2 - 10.1109/BIBE55377.2022.00014
DO - 10.1109/BIBE55377.2022.00014
M3 - Conference contribution
AN - SCOPUS:85145597188
T3 - Proceedings - IEEE 22nd International Conference on Bioinformatics and Bioengineering, BIBE 2022
SP - 29
EP - 32
BT - Proceedings - IEEE 22nd International Conference on Bioinformatics and Bioengineering, BIBE 2022
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 22nd IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2022
Y2 - 7 November 2022 through 9 November 2022
ER -