TY - GEN
T1 - Gridding the spot centers of microarray images
AU - Ho, Jinn
AU - Hwang, Wen Liang
AU - Lu, Henry Horn Shing
AU - Lee, D. T.
PY - 2005/9
Y1 - 2005/9
N2 - We use an optimization technique to accurately locate a distorted grid structure in a microarray image. By assuming that spot centers deviate smoothly from a checkerboard grid structure, we show that the process of gridding spot centers can be formulated as a constrained optimization problem. The constraint is equal to the variations of the transform parameter. We demonstrate the accuracy of our algorithm on two sets of microarray images. One set consists of some images from the Stanford Microarray Database; we compare our centers with those annotated in the Database. The other set consists of oligonucleotide images. We compare our results with those obtained by GenePix Pro 5.0. Our experiments were performed completely automatically.
AB - We use an optimization technique to accurately locate a distorted grid structure in a microarray image. By assuming that spot centers deviate smoothly from a checkerboard grid structure, we show that the process of gridding spot centers can be formulated as a constrained optimization problem. The constraint is equal to the variations of the transform parameter. We demonstrate the accuracy of our algorithm on two sets of microarray images. One set consists of some images from the Stanford Microarray Database; we compare our centers with those annotated in the Database. The other set consists of oligonucleotide images. We compare our results with those obtained by GenePix Pro 5.0. Our experiments were performed completely automatically.
UR - http://www.scopus.com/inward/record.url?scp=84863650465&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84863650465
SN - 1604238216
SN - 9781604238211
T3 - 13th European Signal Processing Conference, EUSIPCO 2005
SP - 596
EP - 599
BT - 13th European Signal Processing Conference, EUSIPCO 2005
T2 - 13th European Signal Processing Conference, EUSIPCO 2005
Y2 - 4 September 2005 through 8 September 2005
ER -