TY - JOUR
T1 - Graphene oxide as broadband hyperthermic agent and chemo-photothermal dissolution of kidney-stone mimicking calcium oxalate crystals
AU - Chen, Hung You
AU - Ghosh, Sandip
AU - Ponnusamy, Vinoth Kumar
AU - Chattopadhyay, Surojit
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/1/15
Y1 - 2021/1/15
N2 - Graphene oxide (GO) and gold nanorods (AuNRs) have been extensively evaluated for broadband (325-980 nm) photothermal (PT) heat generation and efficiency, on substrates having contrasting thermal conductivities. Infrared thermal imaging of the PT agents under broadband irradiation showed a maximum rise of local temperature of chicken kidney tissue by 16.4, and 5.7 °C for GO and AuNR, respectively, under similar irradiation conditions. The PT conversion efficiency, derived from the cooling curves of the dynamic PT response, was found to be exceeding 60 % for GO on chicken kidney tissue under 532, 785, and 980 nm laser irradiations. The PT effect was used to enhance the dissolution rate of the kidney stone mimicking calcium oxalate crystals in the presence of hydroxyanthraquinone (AQ) solution. Mass spectrometric experiments show that the combination of AQ and GO, when irradiated with 532 nm, could chemo-photothermally dissolve calcium oxalate by at least ∼20 % more than when using AQ alone, or using a resistive way of elevating the solution temperature.
AB - Graphene oxide (GO) and gold nanorods (AuNRs) have been extensively evaluated for broadband (325-980 nm) photothermal (PT) heat generation and efficiency, on substrates having contrasting thermal conductivities. Infrared thermal imaging of the PT agents under broadband irradiation showed a maximum rise of local temperature of chicken kidney tissue by 16.4, and 5.7 °C for GO and AuNR, respectively, under similar irradiation conditions. The PT conversion efficiency, derived from the cooling curves of the dynamic PT response, was found to be exceeding 60 % for GO on chicken kidney tissue under 532, 785, and 980 nm laser irradiations. The PT effect was used to enhance the dissolution rate of the kidney stone mimicking calcium oxalate crystals in the presence of hydroxyanthraquinone (AQ) solution. Mass spectrometric experiments show that the combination of AQ and GO, when irradiated with 532 nm, could chemo-photothermally dissolve calcium oxalate by at least ∼20 % more than when using AQ alone, or using a resistive way of elevating the solution temperature.
KW - Broadband
KW - Gold nanorods
KW - Graphene oxide
KW - Kidney Stone
KW - Photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85091756833&partnerID=8YFLogxK
U2 - 10.1016/j.jphotochem.2020.112917
DO - 10.1016/j.jphotochem.2020.112917
M3 - Article
AN - SCOPUS:85091756833
SN - 1010-6030
VL - 405
JO - Journal of Photochemistry and Photobiology A: Chemistry
JF - Journal of Photochemistry and Photobiology A: Chemistry
M1 - 112917
ER -