TY - JOUR
T1 - Glaucoma Detection Using Support Vector Machine Method Based on Spectralis OCT
AU - Wu, Chao Wei
AU - Chen, Hsin Yi
AU - Chen, Jui Yu
AU - Lee, Ching Hung
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2
Y1 - 2022/2
N2 - Spectralis optical coherence tomography (OCT) provided more detailed parameters in the peripapillary and macular areas among the OCT machines, but it is not easy to understand the enor-mous information (114 features) generated from Spectralis OCT in glaucoma assessment. Machine learning methodology has been well-applied in glaucoma detection in recent years and has the abil-ity to process a large amount of information at once. Here we aimed to analyze the diagnostic capability of Spectralis OCT parameters on glaucoma detection using Support Vector Machine (SVM) classification method in our population. Our results showed that applying all OCT features with the SVM method had good capability in the detection of glaucomatous eyes (area under curve (AUC) = 0.82), as well as discriminating normal eyes from early, moderate, or severe glaucomatous eyes (AUC = 0.78, 0.89, and 0.93, respectively). Apart from using all OCT features, the minimum rim width (MRW) may be good feature groups to discriminate early glaucomatous from normal eyes (AUC = 0.78). The combination of peripapillary and macular parameters, including MRW_temporal inferior (TI), MRW_global (G), ganglion cell layer (GCL)_outer temporal (T2), GCL_inner inferior (I1), peripapillary nerve fiber layer thickness (ppNFLT)_temporal superior (TS), and GCL_inner temporal (T1), provided better results (AUC = 0.84). This study showed promise in glaucoma management in the Taiwanese population. However, further validation study is needed to test the per-formance of our proposed model in the real world.
AB - Spectralis optical coherence tomography (OCT) provided more detailed parameters in the peripapillary and macular areas among the OCT machines, but it is not easy to understand the enor-mous information (114 features) generated from Spectralis OCT in glaucoma assessment. Machine learning methodology has been well-applied in glaucoma detection in recent years and has the abil-ity to process a large amount of information at once. Here we aimed to analyze the diagnostic capability of Spectralis OCT parameters on glaucoma detection using Support Vector Machine (SVM) classification method in our population. Our results showed that applying all OCT features with the SVM method had good capability in the detection of glaucomatous eyes (area under curve (AUC) = 0.82), as well as discriminating normal eyes from early, moderate, or severe glaucomatous eyes (AUC = 0.78, 0.89, and 0.93, respectively). Apart from using all OCT features, the minimum rim width (MRW) may be good feature groups to discriminate early glaucomatous from normal eyes (AUC = 0.78). The combination of peripapillary and macular parameters, including MRW_temporal inferior (TI), MRW_global (G), ganglion cell layer (GCL)_outer temporal (T2), GCL_inner inferior (I1), peripapillary nerve fiber layer thickness (ppNFLT)_temporal superior (TS), and GCL_inner temporal (T1), provided better results (AUC = 0.84). This study showed promise in glaucoma management in the Taiwanese population. However, further validation study is needed to test the per-formance of our proposed model in the real world.
KW - Glaucoma
KW - Optical coherence tomography (OCT)
KW - Supported vector machine (SVM)
UR - http://www.scopus.com/inward/record.url?scp=85124091731&partnerID=8YFLogxK
U2 - 10.3390/diagnostics12020391
DO - 10.3390/diagnostics12020391
M3 - Article
AN - SCOPUS:85124091731
SN - 2075-4418
VL - 12
JO - Diagnostics
JF - Diagnostics
IS - 2
M1 - 391
ER -