Glaucoma, Alzheimer's disease, and Parkinson's disease: An 8-year population-based follow-up study

I. Chan Lin*, Yuan Hung Wang, Tsung Jen Wang, I. Jong Wang, Yun Den Shen, Nai Fang Chi, Li Nien Chien

*此作品的通信作者

研究成果: Article同行評審

63 引文 斯高帕斯(Scopus)

摘要

Background: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.

Objective: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.

Methods: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.

Results: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P=.0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P = .9953).

Conclusion: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.

原文English
文章編號08938
期刊PLoS ONE
9
發行號10
DOIs
出版狀態Published - 2 10月 2014

指紋

深入研究「Glaucoma, Alzheimer's disease, and Parkinson's disease: An 8-year population-based follow-up study」主題。共同形成了獨特的指紋。

引用此