Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow

Diana Le Duc*, Akhil Velluva, Molly Cassatt-Johnstone, Remi Andre Olsen, Sina Baleka, Chen Ching Lin, Johannes R. Lemke, John R. Southon, Alexander Burdin, Ming Shan Wang, Sonja Grunewald, Wilfried Rosendahl, Ulrich Joger, Sereina Rutschmann, Thomas B. Hildebrandt, Guido Fritsch, James A. Estes, Janet Kelso, Love Dalén, Michael HofreiterBeth Shapiro, Torsten Schöneberg

*此作品的通信作者

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Steller's sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller's descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller's sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold aquatic (or marine) environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse models cause ichthyosis, a skin disease characterized by a thick, hyperkeratotic epidermis that recapitulates Steller's sea cows' reportedly bark-like skin. We also found that Steller's sea cows' abundance was continuously declining for tens of thousands of years before their description, implying that environmental changes also contributed to their extinction.

原文English
文章編號eabl6496
期刊Science Advances
8
發行號5
DOIs
出版狀態Published - 2月 2022

指紋

深入研究「Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow」主題。共同形成了獨特的指紋。

引用此