Genome-wide polygenic risk score for predicting high risk glaucoma individuals of han chinese ancestry

Yu Jer Hsiao, Hao Kai Chuang, Sheng Chu Chi, Yung Yu Wang, Pin Hsuan Chiang, Pai Chi Teng, Tung Mei Kuang, Aliaksandr A. Yarmishyn, Tai Chi Lin, De Kuang Hwang, Shih Jen Chen, Shih Hwa Chiou, Mei Ju Chen, Ai Ru Hsieh*, Chih Chien Hsu

*此作品的通信作者

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Glaucoma is a progressive and irreversible blindness-causing disease. However, the underlying genetic factors and molecular mechanisms remain poorly understood. Previous genome-wide association studies (GWAS) have made tremendous progress on the SNP-based disease association and characterization. However, most of them were conducted for Europeans. Since differential genetic characteristics among ethnic groups were evident in glaucoma, it is worthwhile to complete its genetic landscape from the larger cohorts of Asian individuals. Here, we present a GWAS based on the Taiwan Biobank. Among 1013 glaucoma patients and 36,562 controls, we identified a total of 138 independent glaucoma-associated SNPs at the significance level of p < 1 × 10−5 . After clumping genetically linked SNPs (LD clumping), 134 independent SNPs with p < 10−4 were recruited to construct a Polygenic Risk Score (PRS). The model achieved an area under the receiver operating characteristic curve (AUC) of 0.8387 (95% CI = [0.8269–0.8506]), and those within the top PRS quantile had a 45.48-fold increased risk of glaucoma compared with those within the lowest quantile. The PRS model was validated with an independent cohort that achieved an AUC of 0.7283, thereby showing the effectiveness of our polygenic risk score in predicting individuals in the Han Chinese population with higher glaucoma risks.

原文English
文章編號1169
期刊Journal of Personalized Medicine
11
發行號11
DOIs
出版狀態Published - 11月 2021

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