Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

Xiaohui Yan, Jian Jun Chen, Ajeeth Adhikari, Dong Yang, Ivana Crnovcic, Nan Wang, Chin-Yuan Chang, Christoph Rader, Ben Shen*

*此作品的通信作者

研究成果: Article同行評審

41 引文 斯高帕斯(Scopus)

摘要

A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.

原文English
頁(從 - 到)6192-6195
頁數4
期刊Organic Letters
19
發行號22
DOIs
出版狀態Published - 17 11月 2017

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