Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

Xiaohui Yan; Jian Jun Chen; Ajeeth Adhikari; Dong Yang; Ivana Crnovcic; Nan Wang; Chin-Yuan Chang; Christoph Rader; Ben Shen

doi:10.1021/acs.orglett.7b03120

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

Xiaohui Yan, Jian Jun Chen, Ajeeth Adhikari, Dong Yang, Ivana Crnovcic, Nan Wang, Chin-Yuan Chang, Christoph Rader, Ben Shen^*

^*此作品的通信作者

生物科技學系

研究成果: Article › 同行評審

57 引文斯高帕斯（Scopus）

摘要

A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.

原文	English
頁（從 - 到）	6192-6195
頁數	4
期刊	Organic Letters
卷	19
發行號	22
DOIs	https://doi.org/10.1021/acs.orglett.7b03120
出版狀態	Published - 17 11月 2017

UN SDG

此研究成果有助於以下永續發展目標

存取文件

10.1021/acs.orglett.7b03120

其它文件與鏈接

Link to publication in Scopus

引用此

@article{d23428eda4764f5cb497dfe0e303bf3f,

title = "Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne",

abstract = "A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.",

author = "Xiaohui Yan and Chen, {Jian Jun} and Ajeeth Adhikari and Dong Yang and Ivana Crnovcic and Nan Wang and Chin-Yuan Chang and Christoph Rader and Ben Shen",

year = "2017",

month = nov,

day = "17",

doi = "10.1021/acs.orglett.7b03120",

language = "English",

volume = "19",

pages = "6192--6195",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "22",

}

TY - JOUR

T1 - Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

AU - Yan, Xiaohui

AU - Chen, Jian Jun

AU - Adhikari, Ajeeth

AU - Yang, Dong

AU - Crnovcic, Ivana

AU - Wang, Nan

AU - Chang, Chin-Yuan

AU - Rader, Christoph

AU - Shen, Ben

PY - 2017/11/17

Y1 - 2017/11/17

N2 - A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.

AB - A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.

UR - http://www.scopus.com/inward/record.url?scp=85034600378&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.7b03120

DO - 10.1021/acs.orglett.7b03120

M3 - Article

C2 - 29086572

AN - SCOPUS:85034600378

SN - 1523-7060

VL - 19

SP - 6192

EP - 6195

JO - Organic Letters

JF - Organic Letters

IS - 22

ER -

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

摘要

UN SDG

存取文件

其它文件與鏈接

指紋

引用此