Gene rearrangement of cutaneous T-cell lymphoma.

F. S. Fan; S. H. Lin; C. H. Tzeng; M. W. Chuang; J. H. Yang; J. H. Liu; R. K. Hsieh; C. J. Liu; J. M. Liu; M. S. Chen

Gene rearrangement of cutaneous T-cell lymphoma.

F. S. Fan^*, S. H. Lin, C. H. Tzeng, M. W. Chuang, J. H. Yang, J. H. Liu, R. K. Hsieh, C. J. Liu, J. M. Liu, M. S. Chen

^*此作品的通信作者

生物藥學研究所

研究成果: Article › 同行評審

摘要

Gene Rearrangement is considered to be a helpful tool for diagnosis of cutaneous T-cell lymphoma. In this study five patients with clinical diagnosis of cutaneous T-cell lymphoma were reviewed for their clinical presentation, skin biopsies and surface marker phenotypes. Southern blot analysis of DNA extracted from their skins revealed that rearrangement of T-cell receptor beta chain (TCRB) genes happened in three patients but rearrangement of immunoglobulin heavy chain genes was absent. TCRB rearrangement could also detect lymphoma involvement of lymph nodes, peripheral blood and bone marrow in our patients. In these conditions, systemic therapy is suggested.

原文	English
頁（從 - 到）	1-6
頁數	6
期刊	Journal of the Chinese Medical Association
卷	45
發行號	1
出版狀態	Published - 1月 1990

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title = "Gene rearrangement of cutaneous T-cell lymphoma.",

abstract = "Gene Rearrangement is considered to be a helpful tool for diagnosis of cutaneous T-cell lymphoma. In this study five patients with clinical diagnosis of cutaneous T-cell lymphoma were reviewed for their clinical presentation, skin biopsies and surface marker phenotypes. Southern blot analysis of DNA extracted from their skins revealed that rearrangement of T-cell receptor beta chain (TCRB) genes happened in three patients but rearrangement of immunoglobulin heavy chain genes was absent. TCRB rearrangement could also detect lymphoma involvement of lymph nodes, peripheral blood and bone marrow in our patients. In these conditions, systemic therapy is suggested.",

author = "Fan, {F. S.} and Lin, {S. H.} and Tzeng, {C. H.} and Chuang, {M. W.} and Yang, {J. H.} and Liu, {J. H.} and Hsieh, {R. K.} and Liu, {C. J.} and Liu, {J. M.} and Chen, {M. S.}",

year = "1990",

month = jan,

language = "English",

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T1 - Gene rearrangement of cutaneous T-cell lymphoma.

AU - Fan, F. S.

AU - Lin, S. H.

AU - Tzeng, C. H.

AU - Chuang, M. W.

AU - Yang, J. H.

AU - Liu, J. H.

AU - Hsieh, R. K.

AU - Liu, C. J.

AU - Liu, J. M.

AU - Chen, M. S.

PY - 1990/1

Y1 - 1990/1

N2 - Gene Rearrangement is considered to be a helpful tool for diagnosis of cutaneous T-cell lymphoma. In this study five patients with clinical diagnosis of cutaneous T-cell lymphoma were reviewed for their clinical presentation, skin biopsies and surface marker phenotypes. Southern blot analysis of DNA extracted from their skins revealed that rearrangement of T-cell receptor beta chain (TCRB) genes happened in three patients but rearrangement of immunoglobulin heavy chain genes was absent. TCRB rearrangement could also detect lymphoma involvement of lymph nodes, peripheral blood and bone marrow in our patients. In these conditions, systemic therapy is suggested.

AB - Gene Rearrangement is considered to be a helpful tool for diagnosis of cutaneous T-cell lymphoma. In this study five patients with clinical diagnosis of cutaneous T-cell lymphoma were reviewed for their clinical presentation, skin biopsies and surface marker phenotypes. Southern blot analysis of DNA extracted from their skins revealed that rearrangement of T-cell receptor beta chain (TCRB) genes happened in three patients but rearrangement of immunoglobulin heavy chain genes was absent. TCRB rearrangement could also detect lymphoma involvement of lymph nodes, peripheral blood and bone marrow in our patients. In these conditions, systemic therapy is suggested.

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M3 - Article

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AN - SCOPUS:0024986621

SN - 0578-1337

VL - 45

SP - 1

EP - 6

JO - Journal of the Chinese Medical Association

JF - Journal of the Chinese Medical Association

IS - 1

ER -

Gene rearrangement of cutaneous T-cell lymphoma.

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