Gap score and ca-153 associated with one-year mortality in anti-mda-5 antibody-positive patients: A real-world experience

Chih Wei Tseng, Kao Lun Wang, Pin Kuei Fu, Cheng Yi Huang, Tsu Yi Hsieh, Chia Wei Hsieh, Kuo Lung Lai, Wei Ting Hung, Ching Tsai Lin, Kuo Tung Tang, Yi Ming Chen*, Wen Nan Huang, Yi Hsing Chen

*此作品的通信作者

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Background. Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is associated with respiratory failure and death in patients with idiopathic inflammatory myositis (IIM) and interstitial lung disease (ILD). This study aimed to investigate clinical parameters associated with mortality in anti-MDA-5 antibody-positive patients. Methods. We retrospectively reviewed the clinical and laboratory data, and pulmonary function test results in 55 anti-MDA-5 antibody-positive patients. A comparison was made between the survivors and non-survivors at the 12-month follow-up. Results. A total of 13 patients (23.6%) died within 12 months. Non-survivors had higher GAP scores (gender, age, and physiology score for idiopathic pulmonary fibrosis) (1 vs. 6, p < 0.01) and CA-153 (16.4 vs. 72.9, p < 0.01). In addition, rapid progressive ILD, fever, peak ferritin, leukocyte count, lactate dehydrogenase, CT score, intravenous immunoglobulin, mycophenolic acid, CMV infections, pneumocystis pneumonia, and pneumothorax were significantly associated with increased risks of 1-year mortality, while forced vital capacity, forced expiratory volume in one second, and diffusion capacity for carbon monoxide were correlated with decreased risk of 1-year mortality. Conclusions. Our study results suggest that GAP scores and CA-153 could be prognostic factors for 1-year mortality in anti-MDA-5 antibody-positive patients. A prompt pulmonary function test and CA-153 are essential for these patients to guide further management.

原文English
文章編號5241
期刊Journal of Clinical Medicine
10
發行號22
DOIs
出版狀態Published - 1 11月 2021

指紋

深入研究「Gap score and ca-153 associated with one-year mortality in anti-mda-5 antibody-positive patients: A real-world experience」主題。共同形成了獨特的指紋。

引用此