Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins

Keyphrases

• Bcl-2 Family Proteins 100%
• Anti-apoptotic Bcl-2 100%
• BH3 Peptides 36%
• Cytotoxic Activity 27%
• Tumor Cells 18%
• Natural Products 18%
• Peptide Binding 18%
• Cytotoxic Mechanism 18%
• Bfl-1 18%
• Suppression Effect 9%
• Apoptosis 9%
• Concentration-dependent 9%
• IC50 9%
• Cell-based 9%
• Recombinant 9%
• Caspase 9%
• Single-molecule Fluorescence Resonance Energy Transfer (smFRET) 9%
• Protease 9%
• Mitochondria 9%
• Active Compounds 9%
• Cells in Culture 9%
• Competitive Inhibitor 9%
• Inhibition Rate 9%
• Myeloid Cell leukemia-1 (Mcl-1) 9%
• Apoptotic Mechanism 9%
• In Vitro Release 9%
• Tumor Cell Lines 9%
• Fluorescence Resonance Energy Transfer Assay 9%
• High-throughput Screening Assays 9%
• Isolated Mitochondria 9%
• Fluorescence Polarization Assay 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Antiapoptotic 100%
• Gambogic Acid 100%
• Neoplasm 27%
• Cytotoxicity 27%
• Natural Product 18%
• IC50 9%
• Proteinase 9%
• Caspase 9%
• High-Throughput Screening 9%
• Competitive Inhibitor 9%
• Cytoprotective Agent 9%
• Bcl2 Related Protein A1 9%