@article{49f92cd64b1a4d5dbbe41d3437930b7a,
title = "GABAergic neuron death in the striatum following kainate-induced damage of hippocampal neurons: Evidence for the role of no in locomotion",
abstract = "The authors examined the role of nitric oxide (NO) in the relationship between kainate-induced neuronal death and locomotion changes. Locomotion was significantly increased 1 h after kainate injection, suggesting that kainate induced NO and dopamine release. Cell death occurred in the CA1 (41%) and CA3 (54%) regions at 12 h. At 7 days, GABAergic neurons in striatum were lost, suggesting possible pyramidal neuron synapse with striatal GABAergic neurons, and pyramidal neuron damage leading to deafferentation and degeneration of striatal GABAergic neurons. Pre-administration of Nw-nitro-L- arginine-methyl-ester or 7-nitroindazole reduced these effects. These results indicate that NO may modulate kainate-induced neuronal death and locomotion.",
keywords = "7-nitroindazole, Kainate, Locomotion, N-nitro-L- arginine methyl ester, Neuronal death, NO",
author = "Shih, {Yang Hsin} and Lee, {Ai Wei} and Huang, {Yn Ho} and Ko, {Miau Hwa} and Fu, {Yu Show}",
note = "Funding Information: Received 21 October 2003. This work was supported by Grants NSC 89-2314-B010-025 and NSC 89-2314-B-075-048 from the National Science Council, Grants Cl-92-3-1 and Cl-92-3-2 from Yen Tjing Ling Medical Foundation and CMC91-M-31 from China Medical University, Taiwan. Address correspondence to Yu-Show Fu, Department of Anatomy, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Li-Nung Street, Taipei, Taiwan, 112, R.O.C. E-mail: ysfu@ym.edu.tw",
year = "2004",
month = sep,
doi = "10.1080/00207450490475616",
language = "English",
volume = "114",
pages = "1119--1132",
journal = "International Journal of Neuroscience",
issn = "0020-7454",
publisher = "Informa Healthcare",
number = "9",
}