GABAergic neuron death in the striatum following kainate-induced damage of hippocampal neurons: Evidence for the role of no in locomotion

Yang Hsin Shih, Ai Wei Lee, Yn Ho Huang, Miau Hwa Ko, Yu Show Fu*

*此作品的通信作者

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

The authors examined the role of nitric oxide (NO) in the relationship between kainate-induced neuronal death and locomotion changes. Locomotion was significantly increased 1 h after kainate injection, suggesting that kainate induced NO and dopamine release. Cell death occurred in the CA1 (41%) and CA3 (54%) regions at 12 h. At 7 days, GABAergic neurons in striatum were lost, suggesting possible pyramidal neuron synapse with striatal GABAergic neurons, and pyramidal neuron damage leading to deafferentation and degeneration of striatal GABAergic neurons. Pre-administration of Nw-nitro-L- arginine-methyl-ester or 7-nitroindazole reduced these effects. These results indicate that NO may modulate kainate-induced neuronal death and locomotion.

原文English
頁(從 - 到)1119-1132
頁數14
期刊International Journal of Neuroscience
114
發行號9
DOIs
出版狀態Published - 9月 2004

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