Functional connectivity altering in hippocampus with closed-loop deep brain stimulation

Cihun Siyong Alex Gong*, Yuan Ting Tsai, Ji An Chen, Hsin Yi Lai, Wei Che Wei, You Yin Chen

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

Hippocampus is considered as the main role of memory consolidation. Learning can be completed after memory consolidation. The thalamus plays an important role in consciousness. In past research had supported that that stimulation in the central lateral thalamus could enhance the learning behavioral. Here, we present an investigational platform including: an implanted sensing and stimulation components to collect data and run the closed-loop algorithm with real-time spectrum measurement. The prototyping system was demonstrated in a chronic animal model studying hippocampal dynamics. We used the platform to find the biomarker, that the theta (θ) spectral band power of local field potentials (LFPs) could be a control variable of interest when modulating hippocampal network state after central lateral thalamic stimulation. The platform is designed to be a flexible prototyping tool and could be used to develop improved mechanistic models and automated closed-loop systems for a variety of neurological disorders.

原文English
主出版物標題Digest of Technical Papers - IEEE International Conference on Consumer Electronics
發行者Institute of Electrical and Electronics Engineers Inc.
頁面7-8
頁數2
ISBN(電子)9781479938308
DOIs
出版狀態Published - 18 9月 2014
事件1st IEEE International Conference on Consumer Electronics - Taiwan, ICCE-TW 2014 - Taipei, Taiwan
持續時間: 26 5月 201428 5月 2014

出版系列

名字Digest of Technical Papers - IEEE International Conference on Consumer Electronics
ISSN(列印)0747-668X

Conference

Conference1st IEEE International Conference on Consumer Electronics - Taiwan, ICCE-TW 2014
國家/地區Taiwan
城市Taipei
期間26/05/1428/05/14

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