TY - GEN
T1 - Functional connectivity altering in hippocampus with closed-loop deep brain stimulation
AU - Gong, Cihun Siyong Alex
AU - Tsai, Yuan Ting
AU - Chen, Ji An
AU - Lai, Hsin Yi
AU - Wei, Wei Che
AU - Chen, You Yin
N1 - Publisher Copyright:
© 2014 IEEE.
PY - 2014/9/18
Y1 - 2014/9/18
N2 - Hippocampus is considered as the main role of memory consolidation. Learning can be completed after memory consolidation. The thalamus plays an important role in consciousness. In past research had supported that that stimulation in the central lateral thalamus could enhance the learning behavioral. Here, we present an investigational platform including: an implanted sensing and stimulation components to collect data and run the closed-loop algorithm with real-time spectrum measurement. The prototyping system was demonstrated in a chronic animal model studying hippocampal dynamics. We used the platform to find the biomarker, that the theta (θ) spectral band power of local field potentials (LFPs) could be a control variable of interest when modulating hippocampal network state after central lateral thalamic stimulation. The platform is designed to be a flexible prototyping tool and could be used to develop improved mechanistic models and automated closed-loop systems for a variety of neurological disorders.
AB - Hippocampus is considered as the main role of memory consolidation. Learning can be completed after memory consolidation. The thalamus plays an important role in consciousness. In past research had supported that that stimulation in the central lateral thalamus could enhance the learning behavioral. Here, we present an investigational platform including: an implanted sensing and stimulation components to collect data and run the closed-loop algorithm with real-time spectrum measurement. The prototyping system was demonstrated in a chronic animal model studying hippocampal dynamics. We used the platform to find the biomarker, that the theta (θ) spectral band power of local field potentials (LFPs) could be a control variable of interest when modulating hippocampal network state after central lateral thalamic stimulation. The platform is designed to be a flexible prototyping tool and could be used to develop improved mechanistic models and automated closed-loop systems for a variety of neurological disorders.
UR - http://www.scopus.com/inward/record.url?scp=84907737332&partnerID=8YFLogxK
U2 - 10.1109/ICCE-TW.2014.6904106
DO - 10.1109/ICCE-TW.2014.6904106
M3 - Conference contribution
AN - SCOPUS:84907737332
T3 - Digest of Technical Papers - IEEE International Conference on Consumer Electronics
SP - 7
EP - 8
BT - Digest of Technical Papers - IEEE International Conference on Consumer Electronics
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 1st IEEE International Conference on Consumer Electronics - Taiwan, ICCE-TW 2014
Y2 - 26 May 2014 through 28 May 2014
ER -