Functional aliphatic polyesters and nanoparticles prepared by organocatalysis and orthogonal grafting chemistry

Angela L. Silvers, Chia Chih Chang, Todd Emrick*

*此作品的通信作者

研究成果: Article同行評審

37 引文 斯高帕斯(Scopus)

摘要

We describe the use of organic catalysis for the ring-opening polymerization of functionalized lactones and conversion of the resulting aliphatic polyesters into crosslinked nanoparticles that carry additional functional groups amenable to further modification. Specifically, highly functional aliphatic polyester homopolymers, as well as random and block copolymers, were prepared by 1,5,7-triazabicyclo[4.4.0]dec-5-ene catalysis, giving polyesters with pendent alkene and alkyne groups. Azide-alkyne click and thiol-ene chemistries were used for postpolymerization modification of diblock copolymers possessing alkene groups on one block and alkyne groups on the other block. The polyesters were crosslinked using azide/alkyne cycloaddition, by reaction of α,ω-diazides with the pendent alkynes on the polyester backbone. This gave polyester nanoparticles possessing alkene functionality, which were subjected to further modification using thiol-ene reactions to introduce additional functionality.

原文English
頁(從 - 到)3517-3529
頁數13
期刊Journal of Polymer Science, Part A: Polymer Chemistry
50
發行號17
DOIs
出版狀態Published - 1 9月 2012

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