TY - JOUR
T1 - Formation and characterization of hydrogenated soybean lecithin/TPGS nano-dispersions as a potential carrier for active herbal agents
AU - Shen, Po Tsun
AU - Chiu, Shih Wei
AU - Chang, Jia Yaw
AU - Chung, Tze Wen
AU - Liang, Chia Hua
AU - Deng, Ming Jay
AU - Chou, Tzung Han
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/2/20
Y1 - 2021/2/20
N2 - The goal of this study was to examine the effects of lipid composition on physicochemical characteristics of hydrogenated soybean lecithin (HL)/d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) dispersions using dynamic light scattering, transmission electron microscopy, differential scanning calorimetry, and fluorescence polarization spectroscopy. Our results showed that HL-rich nano-dispersions exhibited larger size, narrower size distribution, higher negative zeta potential, more obvious phase transition regions, and lower membrane fluidity than did the TPGS-rich ones. The membrane packing order, intermolecular attraction interaction, and molecular cooperativity in the phase transition region of the HL dispersions could be reduced by the incorporation of a large amount of TPGS. Furthermore, chemical stability, a drug release profile, and free radical-scavenging capacity of HL/TPGS nano-dispersions encapsulating black soybean seed coat extract (BE) were analyzed. HL/TPGS nano-dispersions improved the stability and radical-scavenging capacity of phytochemicals, such as BE. Nano-dispersions with the molar ratio of HL/TPGS = 9/1 exhibited good storage stability, a slow BE release rate, good free radical-scavenging capacity, and high in vitro biocompatibility; thus, they could be a high-potential vehicle for carrying active herbal agents.
AB - The goal of this study was to examine the effects of lipid composition on physicochemical characteristics of hydrogenated soybean lecithin (HL)/d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) dispersions using dynamic light scattering, transmission electron microscopy, differential scanning calorimetry, and fluorescence polarization spectroscopy. Our results showed that HL-rich nano-dispersions exhibited larger size, narrower size distribution, higher negative zeta potential, more obvious phase transition regions, and lower membrane fluidity than did the TPGS-rich ones. The membrane packing order, intermolecular attraction interaction, and molecular cooperativity in the phase transition region of the HL dispersions could be reduced by the incorporation of a large amount of TPGS. Furthermore, chemical stability, a drug release profile, and free radical-scavenging capacity of HL/TPGS nano-dispersions encapsulating black soybean seed coat extract (BE) were analyzed. HL/TPGS nano-dispersions improved the stability and radical-scavenging capacity of phytochemicals, such as BE. Nano-dispersions with the molar ratio of HL/TPGS = 9/1 exhibited good storage stability, a slow BE release rate, good free radical-scavenging capacity, and high in vitro biocompatibility; thus, they could be a high-potential vehicle for carrying active herbal agents.
KW - D-α-tocopheryl polyethylene glycol 1000 succinate
KW - Free radical-scavenging capacity
KW - In vitro biocompatibility
KW - Physicochemical properties
KW - Thermotropic phase behavior
UR - http://www.scopus.com/inward/record.url?scp=85095773100&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfa.2020.125796
DO - 10.1016/j.colsurfa.2020.125796
M3 - Article
AN - SCOPUS:85095773100
SN - 0927-7757
VL - 611
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
M1 - 125796
ER -