Focal adhesions function as a mechanosensor

Jean Cheng Kuo*

*此作品的通信作者

研究成果: Chapter同行評審

27 引文 斯高帕斯(Scopus)

摘要

Focal adhesions (FAs) are complex plasma membrane-associated macromolecular assemblies that engage with the surrounding extracellular matrix (ECM) via integrin receptors and physically connect with the actin cytoskeleton through the recruitment of numerous FA-associated proteins. FAs undergo a maturation process, which is known to be induced by biochemical or physical cues, to grow and change composition. Varying FA size, distribution, dynamics, and compositions during maturation process is required for transducing the specific signaling networks that reflect the requirements of a cell to sense, adapt, and response to a variety of the environments. While advances have been demonstrated in understanding how important FAs are in mediating various biological processes, less is known about how FA composition is regulated and coordinately transduces the specific signals in mediating the distinct biological outcomes, especially cell migration.

原文English
主出版物標題Progress in Molecular Biology and Translational Science
發行者Elsevier B.V.
頁面55-73
頁數19
DOIs
出版狀態Published - 2014

出版系列

名字Progress in Molecular Biology and Translational Science
126
ISSN(列印)1877-1173
ISSN(電子)1878-0814

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