Fast incorporation of primary amine group into polylactide surface for improving C 2 C 12 cell proliferation using nitrogen-based atmospheric-pressure plasma jets

Yi Wei Yang, Jane Yii Wu, Chih Tung Liu, Guo Chun Liao, Hsuan Yu Huang, Ray Quen Hsu, Ming Hung Chiang, Jong-Shinn Wu*

*此作品的通信作者

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)

摘要

In this article, we report the development of the fast incorporation of primary amine functional groups into a polylactide (PLA) surface using the post-discharge jet region of an atmospheric-pressure nitrogen-based dielectric barrier discharge (DBD). Plasma treatments were carried out in two sequential steps: (1) nitrogen with 0.1% oxygen addition, and (2) nitrogen with 5% ammonia addition. The analyses show that the concentration of N/C ratio, surface energy, contact angle, and surface roughness of the treated PLA surface can reach 19.1%, 70.5 mJ/m2, 38°and 73.22 nm, respectively. In addition, the proposed two-step plasma treatment procedure can produce a PLA surface exhibiting almost the same C2C12 cell attachment and proliferation performance as that of the conventional gelatin coating method. Most importantly, the processing/preparation time is reduced from 13-15 h (gelatin coating method) to 5-15 min (two-step plasma treatment), which is very useful in practical applications.

原文English
頁(從 - 到)160-169
頁數10
期刊Journal of Biomedical Materials Research - Part A
102
發行號1
DOIs
出版狀態Published - 1月 2014

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