Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation

Hsiao Wei Wang, Chung-Wei Cheng, Ching Wen Li, Han Wei Chang, Ping Han Wu, Gou Jen Wang*

*此作品的通信作者

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)

摘要

One of the persistent challenges confronting tissue engineering is the lack of intrinsic microvessels for the transportation of nutrients and metabolites. An artificial microvascular system could be a feasible solution to this problem. In this study, the femtosecond laser ablation technique was implemented for the fabrication of pillared microvessel scaffolds of polylactic-co-glycolic acid (PLGA). This novel scaffold facilitates implementation of the conventional cell seeding process. The progress of cell growth can be observed in vitro by optical microscopy. The problems of becoming milky or completely opaque with the conventional PLGA scaffold after cell seeding can be resolved. In this study, PLGA microvessel scaffolds consisting of 47 μm × 80 μm pillared branches were produced. Results of cell culturing of bovine endothelial cells demonstrate that the cells adhere well and grow to surround each branch of the proposed pillared microvessel networks.

原文English
頁(從 - 到)1865-1873
頁數9
期刊International Journal of Nanomedicine
7
DOIs
出版狀態Published - 5 十二月 2012

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