Fabrication of PEG hydrogel microstructures in microfluidic system for multicellular spheroid formation, culturing and analysis

Chien Yu Fu*, Sheng Yang Tseng, Shih Mo Yang, Long Hsu, Cheng Hsien Liu, Hwan You Chang

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

This study presents a novel microfluidic device for 3-dimension cell culturing and analysis. Through defining the exposure to ultra-violet light by a photomask, localized photopolymerization of poly (ethylene glycol) diacrylate hydrogels form biocompatible and permselective microstructures within a microfluidic device. The designed geometry of microstructures allowed cells to be trapped into structures and to form spheroids in situ. Subsequent analysis and long-term three-dimension cell culture can achieve within the same device. This technique may apply as a microscale bioreactor or a platform for spheroid-based drug screening and study.

原文English
主出版物標題Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
頁面98-100
頁數3
出版狀態Published - 13 6月 2011
事件Nanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
持續時間: 13 6月 201116 6月 2011

出版系列

名字Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
3

Conference

ConferenceNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
國家/地區United States
城市Boston, MA
期間13/06/1116/06/11

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