Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma

Yi Fen Wang, Chun Ju Chang, Chin Ping Lin, Shyue Yih Chang, Pen Yuan Chu, Shyh Kuan Tai, Wing Yin Li, K. S.Clifford Chao, Yu Jen Chen*

*此作品的通信作者

研究成果: Article同行評審

49 引文 斯高帕斯(Scopus)

摘要

Background. Recent studies have indicated hedgehog pathway plays a role in carcinogenesis of certain cancers. We investigated the clinical significance of its signaling components, including Sonic hedgehog (Shh), Patched (Ptch), and Gli-1, in oral squamous cell carcinoma (OSCC). Methods. By immunohistochemistry, we determined Shh, Ptch, and Gli-1 expression in surgical specimens from 40 patients with OSCC. The relationship between expression of these molecules and clinicopathologic variables were assessed by chi-square analysis. Statistical difference of survival was compared using log-rank test. Results. Ptch overexpression was associated with lymphatic metastasis (p =.028). Nuclear Gli-1 overexpression correlated with primary tumor size (p =.001), lymphatic metastasis (p =.011), and tumor recurrence (p =.008). Overexpression of Ptch (p =.020) or Gli-1 (p =.002) in OSCC indicated poor prognosis in the univariate survival analysis. Conclusion. Our results suggest sonic hedgehog (Shh) pathway plays an important role in OSCC progression and should be considered a potential therapeutic target.

原文English
頁(從 - 到)1556-1561
頁數6
期刊Head and Neck
34
發行號11
DOIs
出版狀態Published - 11月 2012

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