TY - JOUR
T1 - Exposure assessment of PM2.5 and urinary 8-OHdG for diesel exhaust emission inspector
AU - Lee, Mei Wen
AU - Chen, Mei Lien
AU - Lung, Shih Chun Candice
AU - Tsai, Chung Jung
AU - Yin, Xin Jie
AU - Mao, I. Fang
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Animal studies have shown exposure to diesel exhaust particles (DEPs) to induce production of reactive oxygen species (ROSs) and increase levels of 8-hydroxydeoxyquanosine (8-OHdG). Controversial results have been obtained regarding the effects of workplace exposure on urinary 8-OHdG level. This study assessed concentrations of environmental PM2.5 in DEP (DEP2.5), personal DEP2.5 and urinary 8-OHdG of diesel engine exhaust emission inspector (inspector) at a diesel vehicle emission inspection station (inspection station). The analysis specifically focuses on the factors that influence inspector urinary 8-OHdG. Repeated-measures study design was used to sample for five consecutive days. A total of 25 environmental PM2.5 measurements were analyzed at 5 different locations by using a dichotomous sampler, and a total of 55 personal PM2.5 measurements were analyzed from inspectors by using PM2.5 personal sampler. During the sampling period, a total of 110 pre- and post-work urine samples from inspectors, and 32 samples from the control group were collected. Following age and sex matching between the inspectors and the control group, levels of urinary 8-OHdG were analyzed. Environmental and personal concentrations of DEP2.5 were 107.25 ± 39.76 (mean ± SD) and 155.96 ± 75.70 μg/m3, respectively. Also, the concentration of urinary 8-OHdG differed significantly between inspector and control non-smokers, averaging 14.05 ± 12.71 and 6.58 ± 4.39 μg/g creatinine, respectively. Additionally, urinary 8-OHdG concentrations were associated with diesel exposure after controlling for smoking and cooking at home. Compared with the control group, the inspector displayed significantly increased levels of urinary 8-OHdG. Diesel exhaust is the single pollutant involved in the exposure of DEP2.5 at the inspection station, as confirmed by the final results.
AB - Animal studies have shown exposure to diesel exhaust particles (DEPs) to induce production of reactive oxygen species (ROSs) and increase levels of 8-hydroxydeoxyquanosine (8-OHdG). Controversial results have been obtained regarding the effects of workplace exposure on urinary 8-OHdG level. This study assessed concentrations of environmental PM2.5 in DEP (DEP2.5), personal DEP2.5 and urinary 8-OHdG of diesel engine exhaust emission inspector (inspector) at a diesel vehicle emission inspection station (inspection station). The analysis specifically focuses on the factors that influence inspector urinary 8-OHdG. Repeated-measures study design was used to sample for five consecutive days. A total of 25 environmental PM2.5 measurements were analyzed at 5 different locations by using a dichotomous sampler, and a total of 55 personal PM2.5 measurements were analyzed from inspectors by using PM2.5 personal sampler. During the sampling period, a total of 110 pre- and post-work urine samples from inspectors, and 32 samples from the control group were collected. Following age and sex matching between the inspectors and the control group, levels of urinary 8-OHdG were analyzed. Environmental and personal concentrations of DEP2.5 were 107.25 ± 39.76 (mean ± SD) and 155.96 ± 75.70 μg/m3, respectively. Also, the concentration of urinary 8-OHdG differed significantly between inspector and control non-smokers, averaging 14.05 ± 12.71 and 6.58 ± 4.39 μg/g creatinine, respectively. Additionally, urinary 8-OHdG concentrations were associated with diesel exposure after controlling for smoking and cooking at home. Compared with the control group, the inspector displayed significantly increased levels of urinary 8-OHdG. Diesel exhaust is the single pollutant involved in the exposure of DEP2.5 at the inspection station, as confirmed by the final results.
KW - Diesel exhaust
KW - Occupational exposure
KW - PM
KW - Urinary 8-OHdG
UR - http://www.scopus.com/inward/record.url?scp=70749132806&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2009.10.012
DO - 10.1016/j.scitotenv.2009.10.012
M3 - Article
C2 - 19896169
AN - SCOPUS:70749132806
SN - 0048-9697
VL - 408
SP - 505
EP - 510
JO - Science of the Total Environment
JF - Science of the Total Environment
IS - 3
ER -